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Since penicillin was introduced in the 1940s, scientists have developed more than 150 antibiotics to help stop the spread of infectious disease. But although these drugs have saved millions of lives, the misuse of antibiotics has caused problems. Their frequent use, often for conditions or infections that aren’t caused by bacteria, has given rise to bacteria that are resistant to many commonly used antibiotics.

Superbugs emerge when an antibiotic fails to kill all of the bacteria it targets, and the surviving bacteria become resistant to that particular drug and frequently other antibiotics as well. Doctors then prescribe a stronger antibiotic, but the bacteria quickly learn to withstand the more potent drug as well, perpetuating a cycle in which increasingly powerful drugs are required to treat infections.

Antibiotic-resistant strains of bacteria began to appear soon after penicillin was introduced. Today, antibiotic-resistant strains have become common, and bacteria resistant to a number of antibiotics have developed. Once only seen in hospitals, outbreaks of some resistant strains — such as methicillin-resistant Staphylococcus aureus (MRSA) — are appearing in the wider community.

For years, the potent antibiotic vancomycin (Vancocin) was a reliable last defense against certain severe infections, notably those caused by staphylococcus bacteria. But in recent years, some superbugs have become able to resist vancomycin.

While experts are working to develop new antibiotics and other treatments to keep pace with antibiotic-resistant strains of bacteria, infectious organisms adapt quickly. Antibiotic-resistant bacteria will continue to be a global health concern — and using antibiotics wisely is an important part of preventing their spread.

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